McTigue Lab Research    

Discovery theme 1: Understanding myelin biology after SCI

 

After traumatic spinal cord injury, adult progenitor (NG2+) cells proliferate and their progeny differentiate into new oligodendrocytes that remyelinate spared axons. Identifying and understanding the mechanisms that drive spontaneous repair processes such as these is important so that beneficial plasticity is not inadvertently interrupted. Select McTigue lab publications in this theme include:

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Discovery theme 2: Understanding liver & systemic metabolic pathology after SCI

 

The liver is essential for numerous physiological processes, including filtering blood and regulating iron storage and release. The liver is also an important immune organ and plays a critical role in response to infection and injury. Liver functions are regulated by autonomic parasympathetic innervation from the brainstem and sympathetic innervation from the thoracic spinal cord. The McTigue lab has shown that key liver functions become dramatically altered by SCI and influence injury outcomes. McTigue lab papers in this theme include:

 

Check out the full list of Mctigue Lab research publications here!

Current McTigers

Lori Hudson, Lab manager

Ping Wei, Technician

Christina Lepak, Technician

Rochelle Diebert, Technician

Christina Marion, Post-doc

Damon DiSabato, Post-doc

Nicki Pukos, Post-doc

Anthony Alfredo, PhD student

Yonaida Valentine, PhD student

Matt Wainstein, Masters student

Nafisa Noor, Undergraduate 

Rahwa Ghenbot, Undergraduate

McTigue Lab PhD and Post-doc Alum

  • Nicki Pukos, PhD - currently a Research Scientist at Sarepta Therapeutics

  • Matt Goodus, PhD - Craig H. Neilsen post-doctoral fellow

  • Zoe Hesp, PhD - currently a Medical Science Liason, AbbVie

  • Evan Goldstein, PhD - currently a post-doc in the lab of Vittorio Gallo, Children's Research Institute, DC

  • Jamie Church, PhD - currently a postdoc in lab of Jared Schwartzer, Mt Holyoke College, South Hadley, MA

  • Andrew Sauerbeck, PhD - currently an Asst. Prof, Washington University, St. Louis, MO

  • Fatma Rezan Sahinkaya, PhD - currently the Associate Scientific Director, ProEd Communications Inc

  • Akshata Almad, PhD - currently a Research Associate, Children's Hospital of Pennsylvania, PA

  • David Schonberg - currently a Senior Medical Science Liason, Atara Bioterapeutics, Cleveland OH

  • Richa Tripathi, PhD - currently a post-doc in the lab of William Richardson, University College London

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Myelinating GFP+ oligodendrocyte wrapping around axons

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NG2+ glial cell in spinal white matter

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Liver GFP+ macrophages stained for Clec4f  

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NG2 glia and astrocytes 

bordering a spinal cord injury lesion