
McTigue Lab Research
Discovery theme 1: Understanding myelin biology after SCI
After traumatic spinal cord injury, adult progenitor (NG2+) cells proliferate and their progeny differentiate into new oligodendrocytes that remyelinate spared axons. Identifying and understanding the mechanisms that drive spontaneous repair processes such as these is important so that beneficial plasticity is not inadvertently interrupted. Select McTigue lab publications in this theme include:
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Pukos N, Goodus MT, Sahinkaya FR, McTigue DM. Myelin status and oligodendrocyte lineage cells over time after spinal cord injury: What do we know and what still needs to be unwrapped? Glia, 67(11): 2178-2202, 2019.
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Hesp ZC, Suzuki R, Wilson C, Nishiyama A, McTigue DM. Proliferating NG2+ cells are required for complete glial and fibrotic scar formation, maintenance of tissue integrity, and functional recovery after spinal cord injury in mice. J Neurosci 38(6): 1366-1382; 2018
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Church JS, Kigerl KA, Lerch JK, Popovich PG, McTigue DM. TLR4 deficiency impairs oligodendrocyte formation in the injured spinal cord. J Neurosci, 36(23): 6352-64; 2016
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Hesp Z, Goldstein EZ, Miranda C, Kaspar, B, McTigue DM. Chronic oligodendrogenesis and remyelination after spinal cord injury in mice and rats. J Neurosci, 35(3): 1274-90; 2015
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Schonberg DL, Popovich PG, McTigue DM. Oligodendrocyte genesis is differentially influenced by Toll-like receptor (TLR2) and TLR4 mediated intraspinal macrophage activation. J Neuropath Exp Neurol, 66(12):1124-1135; 2007
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Tripathi R, McTigue DM. Prominent oligodendrocyte genesis along the border of spinal contusion lesions. Glia, 55:698-711; 2007
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McTigue DM, Wei, P, Stokes BT. Proliferation of NG2+ cells and altered oligodendrocyte numbers in the contused rat spinal cord. J Neurosci, 21:3392-3400; 2001
Discovery theme 2: Understanding liver & systemic metabolic pathology after SCI
The liver is essential for numerous physiological processes, including filtering blood and regulating iron storage and release. The liver is also an important immune organ and plays a critical role in response to infection and injury. Liver functions are regulated by autonomic parasympathetic innervation from the brainstem and sympathetic innervation from the thoracic spinal cord. The McTigue lab has shown that key liver functions become dramatically altered by SCI and influence injury outcomes. McTigue lab papers in this theme include:
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Sauerbeck AD, Laws JL, Bandaru VVR, Popovich PG, Haughey NJ, McTigue DM Spinal cord injury causes chronic liver pathology in rats. J Neurotrauma, 32: 159-169; 2015
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Goodus MT, Carson KE, Sauerbeck AD, Dey P, Alfredo AN, Popovich PG, Bruno RS, McTigue DM. Liver inflammation at the time of spinal cord injury enhances intraspinal pathology, liver injury, metabolic syndrome and locomotor deficits 342: 113725. 2021 Exp Neurol doi: 10.1016/j.expneurol.2021.113725
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Goodus MT, McTigue DM. Hepatic Dysfunction and Spinal Cord Injury: A vicious cycle of central and peripheral pathology? Exp Neurol, 325, 113160, 2020
Check out the full list of Mctigue Lab research publications here!
Current McTigers
Lori Hudson, Lab manager
Ping Wei, Technician
Christina Lepak, Technician
Rochelle Diebert, Technician
Helya Faraji, Technician
Ana Dias, Research Associate
Christina Marion, Post-doc
Damon DiSabato, Post-doc
Maria Balch, Post-doc
Anthony Alfredo, PhD student
Dina Hafez, Masters student
McTigue Lab PhD and Post-doc Alum
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Yonaida Valentine, PhD student
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Matt Wainstein, MSc
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Nafisa Noor, Undergraduate
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Rahwa Ghenbot, Undergraduate
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Nicki Pukos, PhD - currently a Research Scientist at Sarepta Therapeutics
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Matt Goodus, PhD - Craig H. Neilsen post-doctoral fellow
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Zoe Hesp, PhD - currently a Medical Science Liason, AbbVie
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Evan Goldstein, PhD - currently a post-doc in the lab of Vittorio Gallo, Children's Research Institute, DC
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Jamie Church, PhD - currently a postdoc in lab of Jared Schwartzer, Mt Holyoke College, South Hadley, MA
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Andrew Sauerbeck, PhD - currently an Asst. Prof, Washington University, St. Louis, MO
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Fatma Rezan Sahinkaya, PhD - currently the Associate Scientific Director, ProEd Communications Inc
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Akshata Almad, PhD - currently a Research Associate, Children's Hospital of Pennsylvania, PA
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David Schonberg - currently a Senior Medical Science Liason, Atara Bioterapeutics, Cleveland OH
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Richa Tripathi, PhD - currently a post-doc in the lab of William Richardson, University College London

Myelinating GFP+ oligodendrocyte wrapping around axons

NG2+ glial cell in spinal white matter

Liver GFP+ macrophages stained for Clec4f

NG2 glia and astrocytes
bordering a spinal cord injury lesion